Our
physiology as a whole is well coordinated and timed by an internal clock
mechanism. Disturbing the ‘physiological timing’ may result in various
pathological consequences.
Our
heart rate shows a rhythmic fluctuation with a high at day time and low at
night when we sleep so does the blood pressure. So, for checking your heart
rate or blood pressure, the time at which you measure is important.
Different
drugs are metabolized (degraded) at different rates that depends on the time of
day.
For
example, Alcohol is degraded slowly during day time and faster during night.
That is why you experience ‘more kick’ for a lesser dose of alcohol when you
drink during day time. Since the alcohol is degraded slowly during the day,
more alcohol is retained and accumulated in your circulation for a longer time.
Blood
clots faster during day but takes relatively a longer time at night. Hence, you
tend to bleed more of a cut injury during night rather than during day! Therefore, safe
time for men to have a shave is during day time!!
There
are many more to add to this list of events showing rhythmic fluctuations under the purview of our biological clock.
A recent study shows that mouse when allowed to feed freely
at any time of the day (ad libitum) became obese and soon developed other complications.
Whereas mouse fed with the same calorie food but fed only at restricted timings remained healthy. The moral of the study:
Follow a “restricted time” for eating.
Avoid
continuous eating or eating at irregular timings or wide spread eating times.
This
may result in
·
Increased
Adiposity
·
Increased
Glucose Intolerance
·
Increased
Leptin Resistance
·
Increased
Liver Pathology
·
Increased
Inflammation and
·
Decreased
Motor Coordination
-Dr. P. Kumarasamy
Further reading:
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